Production, formulation, quality control and primary biological studies of [18F]KF for skeletal PET scanning [Persian]
نویسندگان
چکیده مقاله:
[18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O>95%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. Pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. This radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats.
منابع مشابه
production, formulation, quality control and primary biological studies of [18f]kf for skeletal pet scanning [persian]
[18f]kf, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18o]h2o>95%) with high energy protons in nrcam cyclotron. after the extraction of fluoride from enriched water as kf, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable for...
متن کاملProduction, formulation and quality control of [13N]NH3 compound for PET imaging of regional blood flow [Persian]
In this study, 16O(p,α)13N nuclear reaction was chosen as the best method of N-13 production. High purity natural water targets were bombarded by 18 MeV protons with an intensity of 8μA. A production yield of 13.5 mCi/μAh was obtained. Chemical modification of 13N-nitrogen oxides into [13N]NH3 was accomplished using De Varda's catalyst. Chemical, radiochemical and radionuclide purity cont...
متن کاملProduction and quality control of 82mRb and primary PET scans using its radiopharmaceutical for heart examinations [Persian]
According to the importance of positron emitters in nuclear medicine, 82mRb was produced as a member of this group of radiopharmaceuticals. After being converted into an injectable form, enough information was provided for imaging with this radiopharmaceutical. 82mRb with high radioisotopic purity and half-life of 6.5 hours, in chloride form, can be considered as a suitable positron emitt...
متن کاملProduction and quality control of 66Ga as a PET radioisotope
Background: 66Ga (t1/2=9.49 h, β+: 4.153 MeV, γ: 511, 834, 1039, 2752 keV) has a wide range of applications in different fields of medical sciences. Production of 66Ga became one of our main interests, according to its increasing applications in nuclear medicine, particularly in PET imaging. Materials and Methods: 66 Zn (p,n)66Ga reaction was determined as the best choice for the production of ...
متن کاملproduction and quality control of 82mrb and primary pet scans using its radiopharmaceutical for heart examinations [persian]
according to the importance of positron emitters in nuclear medicine, 82mrb was produced as a member of this group of radiopharmaceuticals. after being converted into an injectable form, enough information was provided for imaging with this radiopharmaceutical. 82mrb with high radioisotopic purity and half-life of 6.5 hours, in chloride form, can be considered as a suitable positron emitter for...
متن کاملSynthesis, formulation and quality control of Mebrofenin (BRIDA) as a 99mTc-KIT for cholescintigraphy [Persian]
This article will review the essential chemical structure of IDA derivatives and their biokinetic characteristics as the hepatobiliary agents. The article also presents the procedures of Synthesis, formulation and Quality control of mebrofenin (BRIDA) as a 99mTc-Radiopharmaceuticai kit which is produced in Radioisotope Division of N.R.C. 99mTc-BRiDA has extremely low renal excretion and h...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 12 شماره 1
صفحات 49- 61
تاریخ انتشار 2004-11-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023